InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ID4

Summary

InnateDB Protein

IDBP-64061.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ID4

Protein Name

inhibitor of DNA binding 4, dominant negative helix-loop-helix protein

Synonyms

bHLHb27; IDB4;

Species

Homo sapiens

Ensembl Protein

ENSP00000367972

InnateDB Gene

IDBG-64059 (ID4)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007405	neuroblast proliferation
GO:0007420	brain development
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0021766	hippocampus development
GO:0021895	cerebral cortex neuron differentiation
GO:0022010	central nervous system myelination
GO:0034613	cellular protein localization
GO:0045444	fat cell differentiation
GO:0045599	negative regulation of fat cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048712	negative regulation of astrocyte differentiation
GO:0048715	negative regulation of oligodendrocyte differentiation