InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL1RL2

Summary

InnateDB Protein

IDBP-64115.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL1RL2

Protein Name

interleukin 1 receptor-like 2

Synonyms

IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000264257

InnateDB Gene

IDBG-64113 (IL1RL2)

Protein Structure

UniProt Annotation

Function

Receptor for the interleukin IL36G. Binding to the agonist leads to the activation of NF-kappa-B. {ECO:0000269PubMed:11466363}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004908	interleukin-1 receptor activity
GO:0004909	interleukin-1, Type I, activating receptor activity
GO:0005515	protein binding

Biological Process

GO:0006968	cellular defense response
GO:0007165	signal transduction
GO:0019221	cytokine-mediated signaling pathway
GO:0032755	positive regulation of interleukin-6 production
GO:0045087	innate immune response (InnateDB)
GO:0045582	positive regulation of T cell differentiation
GO:0050727	regulation of inflammatory response
GO:0070498	interleukin-1-mediated signaling pathway

Cellular Component

GO:0005887

integral component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR003599 Immunoglobulin subtype
IPR004074 Interleukin-1 receptor type I/II
IPR004076 Interleukin-1 receptor type 1
IPR007110 Immunoglobulin-like domain

PFAM

PF01582
PF13676

PRINTS

PR01536
PR01538

PIRSF

SMART

SM00255
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt