InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL1RL1

Summary

InnateDB Protein

IDBP-64168.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL1RL1

Protein Name

interleukin 1 receptor-like 1

Synonyms

DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1;

Species

Homo sapiens

Ensembl Protein

ENSP00000233954

InnateDB Gene

IDBG-64166 (IL1RL1)

Protein Structure

UniProt Annotation

Function

Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. {ECO:0000269PubMed:16286016}.

Subcellular Localization

Isoform C: Cell membrane.Isoform B: Secreted.Cell membrane {ECO:0000269PubMed:11478810}; Single-pass type I membrane protein {ECO:0000269PubMed:11478810}.

Disease Associations

Tissue Specificity

Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. {ECO:0000269PubMed:11478810}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	10 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002113	interleukin-33 binding
GO:0002114	interleukin-33 receptor activity
GO:0004896	cytokine receptor activity
GO:0004908	interleukin-1 receptor activity
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding

Biological Process

GO:0002826	negative regulation of T-helper 1 type immune response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0032689	negative regulation of interferon-gamma production
GO:0032754	positive regulation of interleukin-5 production
GO:0035556	intracellular signal transduction
GO:0038172	interleukin-33-mediated signaling pathway
GO:0043032	positive regulation of macrophage activation
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0050729	positive regulation of inflammatory response
GO:0090197	positive regulation of chemokine secretion

Cellular Component

GO:0005576	extracellular region
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR004074 Interleukin-1 receptor type I/II
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set

PFAM

PF01582
PF13676
PF07679

PRINTS

PR01536

PIRSF

SMART

SM00255
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt