Version 5.4
Homo sapiens Gene: IL1RL1
Summary
InnateDB Gene IDBG-64166.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL1RL1
Gene Name interleukin 1 receptor-like 1
Synonyms DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1
Species Homo sapiens
Ensembl Gene ENSG00000115602
Encoded Proteins
IDBP-64168
interleukin 1 receptor-like 1
IDBP-64170
interleukin 1 receptor-like 1
IDBP-295113
interleukin 1 receptor-like 1
IDBP-295114
interleukin 1 receptor-like 1
IDBP-383886
interleukin 1 receptor-like 1
IDBP-383889
interleukin 1 receptor-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20400705
IL1RL1 acts as a negative regulator of TLR2 signalling whereby over-expression of IL1RL1 can dose-dependently attenuate bacterial lipoprotein (BLP)-induced NF-kappaB activation, but is not required for BLP-induced tolerance.
PMID 20427273
IL1RL1 is the receptor for IL33, a factor shown to modulate tryptase expression in mesenchymal cells (MCs), identifying a novel pathway by which MCs exposed to inflammatory cytokines modulate the phenotype of local MCs to shape their immune responses.
PMID 22922442
IL1RL1 (ST2) pre-treatment suppresses cytokine production and inhibits LPS signalling in dendritic cells.
InnateDB Annotation from Orthologs
Summary
PMID 22922442
[Mus musculus] IL1RL1 (ST2) pre-treatment suppresses cytokine production and inhibits LPS signalling in dendritic cells. (Demonstrated in human)
PMID 25786179
[Mus musculus] Cigarette smoke decreases Il1rl1 expression on group 2 innate lymphoid cells while elevating Il1rl1 expression on macrophages and natural killer cells, thus altering Il33 responsiveness within the lung to infection.
Entrez Gene
Summary The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:102311502-102352037
Strand Forward strand
Band q12.1
Transcripts
ENST00000233954 ENSP00000233954
ENST00000311734 ENSP00000310371
ENST00000404917 ENSP00000384822
ENST00000409584 ENSP00000386618
ENST00000447231 ENSP00000409437
ENST00000427077 ENSP00000391120
ENST00000473175
ENST00000463990
ENST00000482701
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 10 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002113 interleukin-33 binding
GO:0002114 interleukin-33 receptor activity
GO:0004896 cytokine receptor activity
GO:0004908 interleukin-1 receptor activity
GO:0005057 receptor signaling protein activity
GO:0005515 protein binding
Biological Process
GO:0002826 negative regulation of T-helper 1 type immune response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0019221 cytokine-mediated signaling pathway
GO:0032689 negative regulation of interferon-gamma production
GO:0032754 positive regulation of interleukin-5 production
GO:0035556 intracellular signal transduction
GO:0038172 interleukin-33-mediated signaling pathway
GO:0043032 positive regulation of macrophage activation
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0050729 positive regulation of inflammatory response
GO:0090197 positive regulation of chemokine secretion
Cellular Component
GO:0005576 extracellular region
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026069
View Gene Order
ENSBTAG00000018571
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.593345 Hs.622416 Hs.66 Hs.731651
RefSeq NM_001282408 NM_003856 NM_016232 XM_006712839
HUGO
OMIM
CCDS CCDS2057 CCDS2058 CCDS74548
HPRD 03123
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca