InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TIMM17B

Summary

InnateDB Protein

IDBP-64288.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TIMM17B

Protein Name

translocase of inner mitochondrial membrane 17 homolog B (yeast)

Synonyms

DXS9822; TIM17B;

Species

Homo sapiens

Ensembl Protein

ENSP00000365766

InnateDB Gene

IDBG-64286 (TIMM17B)

Protein Structure

UniProt Annotation

Function

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

Subcellular Localization

Mitochondrion inner membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expression is abundant in heart and skeletal muscle, intermediate in brain, and weak in pancreas, placenta, kidney and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity

Biological Process

GO:0006626	protein targeting to mitochondrion
GO:0006886	intracellular protein transport
GO:0044267	cellular protein metabolic process
GO:0071806	protein transmembrane transport

Cellular Component

GO:0005744	mitochondrial inner membrane presequence translocase complex
GO:0031305	integral component of mitochondrial inner membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003397 Mitochondrial inner membrane translocase subunit Tim17/Tim22/Tim23/peroxisomal protein PMP24
IPR005678 Mitochondrial inner membrane translocase complex, subunit Tim17

PFAM

PF02466

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O60830

PhosphoSite