Homo sapiens Gene: TIMM17B
Summary
InnateDB Gene IDBG-64286.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TIMM17B
Gene Name translocase of inner mitochondrial membrane 17 homolog B (yeast)
Synonyms DXS9822; TIM17B;
Species Homo sapiens
Ensembl Gene ENSG00000126768
Encoded Proteins
translocase of inner mitochondrial membrane 17 homolog B (yeast)
translocase of inner mitochondrial membrane 17 homolog B (yeast)
translocase of inner mitochondrial membrane 17 homolog B (yeast)
translocase of inner mitochondrial membrane 17 homolog B (yeast)
translocase of inner mitochondrial membrane 17 homolog B (yeast)
translocase of inner mitochondrial membrane 17 homolog B (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is part of the mitochondrial transport TIMM23 complex. TIM translocase complexes facilitate the transport of mitochondrial proteins from the cytosol across the mitochondrial inner membrane and into the mitochondrion. Two alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
This gene encodes a multipass transmembrane protein that forms an integral component of the mitochondrial translocase TIM23 complex. This complex facilitates the transport of mitochondrial proteins from the cytosol across the mitochondrial inner membrane and into the mitochondrion. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome X:48893447-48898143
Strand Reverse strand
Band p11.23
Transcripts
ENST00000376582 ENSP00000365766
ENST00000396779 ENSP00000379999
ENST00000466995 ENSP00000476861
ENST00000495490 ENSP00000477027
ENST00000472645
ENST00000465150 ENSP00000477073
ENST00000490755 ENSP00000477085
ENST00000464663
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Biological Process
GO:0006626 protein targeting to mitochondrion
GO:0006886 intracellular protein transport
GO:0044267 cellular protein metabolic process
GO:0071806 protein transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005744 mitochondrial inner membrane presequence translocase complex
GO:0016021 integral component of membrane
GO:0031305 integral component of mitochondrial inner membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of proteins pathway
Mitochondrial protein import pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O60830
TrEMBL
UniProt Splice Variant
Entrez Gene 10245
UniGene
RefSeq NM_001167947 NM_005834
HUGO HGNC:17310
OMIM 300249
CCDS CCDS55411 CCDS14308
HPRD
IMGT
EMBL AF034790 AF077039 AF196971 AF207550 AJ005895 AK290207 BC010142 BC091473 CH471224
GenPept AAC24694 AAD27772 AAH10142 BAF82896 CAA06752 EAW50741
RNA Seq Atlas 10245