Version 5.4
Homo sapiens Protein: SPON2
Summary
InnateDB Protein IDBP-6466.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPON2
Protein Name spondin 2, extracellular matrix protein
Synonyms DIL-1; DIL1; M-SPONDIN; MINDIN;
Species Homo sapiens
Ensembl Protein ENSP00000290902
InnateDB Gene IDBG-6462 (SPON2)
Protein Structure
UniProt Annotation
Function Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS). {ECO:0000250}.
Subcellular Localization Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in normal lung tissue but not in lung carcinoma cell lines. {ECO:0000269PubMed:10512675}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007411 axon guidance
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000884 Thrombospondin, type 1 repeat
IPR009465 Spondin, N-terminal
PFAM PF00090
PF06468
PRINTS
PIRSF
SMART SM00209
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BUD6
PhosphoSite PhosphoSite-Q9BUD6
TrEMBL D6RIH5
UniProt Splice Variant
Entrez Gene 10417
UniGene Hs.743914
RefSeq NP_036577
HUGO HGNC:11253
OMIM 605918
CCDS CCDS3347
HPRD 16174
IMGT
EMBL AB027466 AC092535 AK074618 AK074770 AY358948 BC002707 BC036341 CH471131
GenPept AAH02707 AAH36341 AAQ89307 AAY40988 BAA85892 BAC11092 BAC11196 EAW82604 EAW82606

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca