InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC2A2

Summary

InnateDB Protein

IDBP-64697.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC2A2

Protein Name

solute carrier family 2 (facilitated glucose transporter), member 2

Synonyms

GLUT2;

Species

Homo sapiens

Ensembl Protein

ENSP00000323568

InnateDB Gene

IDBG-64695 (SLC2A2)

Protein Structure

UniProt Annotation

Function

Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Fanconi-Bickel syndrome (FBS) [MIM:227810]: Rare, well- defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose. {ECO:0000269PubMed:10987651, ECO:0000269PubMed:11044475}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Liver, insulin-producing beta cell, small intestine and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005355	glucose transmembrane transporter activity
GO:0015149	hexose transmembrane transporter activity
GO:0022857	transmembrane transporter activity
GO:0022891	substrate-specific transmembrane transporter activity
GO:0033300	dehydroascorbic acid transporter activity
GO:0055056	D-glucose transmembrane transporter activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006112	energy reserve metabolic process
GO:0008645	hexose transport
GO:0015758	glucose transport
GO:0031018	endocrine pancreas development
GO:0035428	hexose transmembrane transport
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion
GO:0055085	transmembrane transport
GO:0070837	dehydroascorbic acid transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005903	brush border
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002440 Glucose transporter, type 2 (GLUT2)
IPR003663 Sugar/inositol transporter
IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00083
PF07690

PRINTS

PR01191
PR00171

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P11168