Homo sapiens Gene: SLC2A2
Summary
InnateDB Gene IDBG-64695.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC2A2
Gene Name solute carrier family 2 (facilitated glucose transporter), member 2
Synonyms GLUT2;
Species Homo sapiens
Ensembl Gene ENSG00000163581
Encoded Proteins
solute carrier family 2 (facilitated glucose transporter), member 2
solute carrier family 2 (facilitated glucose transporter), member 2
solute carrier family 2 (facilitated glucose transporter), member 2
solute carrier family 2 (facilitated glucose transporter), member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. [provided by RefSeq, Jul 2008]
This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:170996348-171026750
Strand Reverse strand
Band q26.2
Transcripts
ENST00000314251 ENSP00000323568
ENST00000497642 ENSP00000418456
ENST00000469787 ENSP00000417918
ENST00000471379
ENST00000461867 ENSP00000418888
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005355 glucose transmembrane transporter activity
GO:0015149 hexose transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0022891 substrate-specific transmembrane transporter activity
GO:0033300 dehydroascorbic acid transporter activity
GO:0055056 D-glucose transmembrane transporter activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006112 energy reserve metabolic process
GO:0008645 hexose transport
GO:0015758 glucose transport
GO:0031018 endocrine pancreas development
GO:0035428 hexose transmembrane transport
GO:0044281 small molecule metabolic process
GO:0050796 regulation of insulin secretion
GO:0055085 transmembrane transport
GO:0070837 dehydroascorbic acid transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005903 brush border
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Integration of energy metabolism pathway
Transmembrane transport of small molecules pathway
Developmental Biology pathway
Myoclonic epilepsy of Lafora pathway
Facilitative Na+-independent glucose transporters pathway
Glucose transport pathway
Hexose transport pathway
Metabolism of carbohydrates pathway
Regulation of beta-cell development pathway
Regulation of gene expression in beta cells pathway
Regulation of insulin secretion pathway
Metabolism pathway
SLC-mediated transmembrane transport pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
Disease pathway
Glycogen storage diseases pathway
KEGG
Type II diabetes mellitus pathway
Maturity onset diabetes of the young pathway
Carbohydrate digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
FOXA2 and FOXA3 transcription factor networks
Cross-References
SwissProt
TrEMBL C9J0E8
UniProt Splice Variant
Entrez Gene 6514
UniGene Hs.167584 Hs.598186 Hs.611808
RefSeq NM_000340 NM_001278658 NM_001278659
HUGO HGNC:11006
OMIM 138160
CCDS CCDS3215
HPRD 00685
IMGT
EMBL AC061708 AC092918
GenPept
RNA Seq Atlas 6514