Homo sapiens Gene: SLC2A2 | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Gene | IDBG-64695.6 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | SLC2A2 | ||||||||||||||||||||
Gene Name | solute carrier family 2 (facilitated glucose transporter), member 2 | ||||||||||||||||||||
Synonyms | GLUT2 | ||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||
Ensembl Gene | ENSG00000163581 | ||||||||||||||||||||
Encoded Proteins |
solute carrier family 2 (facilitated glucose transporter), member 2
solute carrier family 2 (facilitated glucose transporter), member 2
solute carrier family 2 (facilitated glucose transporter), member 2
solute carrier family 2 (facilitated glucose transporter), member 2
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Protein Structure | |||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||
Summary |
Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. [provided by RefSeq, Jul 2008] This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] |
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Gene Information | |||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||
Genomic Location | Chromosome 3:170996348-171026750 | ||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||
Band | q26.2 | ||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||
NETPATH | |||||||||||||||||||||
REACTOME |
Facilitative Na+-independent glucose transporters pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
Glucose transport pathway
Hexose transport pathway
Regulation of insulin secretion pathway
Integration of energy metabolism pathway
Regulation of gene expression in beta cells pathway
Transmembrane transport of small molecules pathway
Developmental Biology pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Regulation of beta-cell development pathway
Metabolism pathway
SLC-mediated transmembrane transport pathway
Disease pathway
Glycogen storage diseases pathway
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KEGG |
Maturity onset diabetes of the young pathway
Type II diabetes mellitus pathway
Carbohydrate digestion and absorption pathway
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INOH | |||||||||||||||||||||
PID NCI |
FOXA2 and FOXA3 transcription factor networks
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Cross-References | |||||||||||||||||||||
SwissProt | |||||||||||||||||||||
TrEMBL | C9J0E8 | ||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | 6514 | ||||||||||||||||||||
UniGene | Hs.167584 Hs.598186 Hs.611808 | ||||||||||||||||||||
RefSeq | NM_000340 NM_001278658 NM_001278659 | ||||||||||||||||||||
HUGO | HGNC:11006 | ||||||||||||||||||||
OMIM | 138160 | ||||||||||||||||||||
CCDS | CCDS3215 | ||||||||||||||||||||
HPRD | 00685 | ||||||||||||||||||||
IMGT | |||||||||||||||||||||
EMBL | AC061708 AC092918 | ||||||||||||||||||||
GenPept | |||||||||||||||||||||
RNA Seq Atlas | 6514 | ||||||||||||||||||||