InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNIK

Summary

InnateDB Protein

IDBP-64743.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNIK

Protein Name

TRAF2 and NCK interacting kinase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000284483

InnateDB Gene

IDBG-64741 (TNIK)

Protein Structure

UniProt Annotation

Function

Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. {ECO:0000269PubMed:10521462, ECO:0000269PubMed:15342639, ECO:0000269PubMed:19061864, ECO:0000269PubMed:19816403, ECO:0000269PubMed:20159449, ECO:0000269PubMed:21690388}.

Subcellular Localization

Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.

Disease Associations

Tissue Specificity

Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues. {ECO:0000269PubMed:10521462, ECO:0000269PubMed:19816403}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	48 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007010	cytoskeleton organization
GO:0007256	activation of JNKK activity
GO:0016055	Wnt signaling pathway
GO:0031532	actin cytoskeleton reorganization
GO:0035556	intracellular signal transduction
GO:0046777	protein autophosphorylation
GO:0048814	regulation of dendrite morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0055037	recycling endosome
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001180 Citron-like
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00780
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00036
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt