InnateDB Protein
|
IDBP-64752.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
CLEC11A
|
Protein Name
|
C-type lectin domain family 11, member A
|
Synonyms
|
CLECSF3; LSLCL; P47; SCGF;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000250340
|
InnateDB Gene
|
IDBG-64750 (CLEC11A)
|
Protein Structure
|
|
Function |
Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation. {ECO:0000269PubMed:11920266}.
|
Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:11803813}. Secreted {ECO:0000269PubMed:11803813}.
|
Disease Associations |
|
Tissue Specificity |
Expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, the perichondrium and periosteum. Lower levels of expression were detected in spleen, thymus, appendix and fetal liver. {ECO:0000269PubMed:11803813, ECO:0000269PubMed:11920266, ECO:0000269PubMed:9442024, ECO:0000269PubMed:9705843}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
GO:0008284
|
positive regulation of cell proliferation
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001304
C-type lectin
IPR016187
C-type lectin fold
|
PFAM |
PF00059
|
PRINTS |
|
PIRSF |
|
SMART |
SM00034
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9Y240
|
PhosphoSite |
PhosphoSite-Q9Y240
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
6320
|
UniGene |
Hs.512680
|
RefSeq |
NP_002966
|
HUGO |
HGNC:10576
|
OMIM |
604713
|
CCDS |
CCDS12800
|
HPRD |
05277
|
IMGT |
|
EMBL |
AB009244
AF020044
AF087658
AK314141
BC005810
CH471135
|
GenPept |
AAC39569
AAD26533
AAH05810
BAA32404
BAG36831
EAW71896
|
|
|