Version 5.4
Homo sapiens Protein: CLEC11A
Summary
InnateDB Protein IDBP-64752.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLEC11A
Protein Name C-type lectin domain family 11, member A
Synonyms CLECSF3; LSLCL; P47; SCGF;
Species Homo sapiens
Ensembl Protein ENSP00000250340
InnateDB Gene IDBG-64750 (CLEC11A)
Protein Structure
UniProt Annotation
Function Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation. {ECO:0000269PubMed:11920266}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:11803813}. Secreted {ECO:0000269PubMed:11803813}.
Disease Associations
Tissue Specificity Expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, the perichondrium and periosteum. Lower levels of expression were detected in spleen, thymus, appendix and fetal liver. {ECO:0000269PubMed:11803813, ECO:0000269PubMed:11920266, ECO:0000269PubMed:9442024, ECO:0000269PubMed:9705843}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008083 growth factor activity
GO:0030246 carbohydrate binding
Biological Process
GO:0008284 positive regulation of cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001304 C-type lectin
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y240
PhosphoSite PhosphoSite-Q9Y240
TrEMBL
UniProt Splice Variant
Entrez Gene 6320
UniGene Hs.512680
RefSeq NP_002966
HUGO HGNC:10576
OMIM 604713
CCDS CCDS12800
HPRD 05277
IMGT
EMBL AB009244 AF020044 AF087658 AK314141 BC005810 CH471135
GenPept AAC39569 AAD26533 AAH05810 BAA32404 BAG36831 EAW71896

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca