Homo sapiens Protein: KCND1 | |||||||||||||
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Summary | |||||||||||||
InnateDB Protein | IDBP-64950.5 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | KCND1 | ||||||||||||
Protein Name | potassium voltage-gated channel, Shal-related subfamily, member 1 | ||||||||||||
Synonyms | KV4.1; | ||||||||||||
Species | Homo sapiens | ||||||||||||
Ensembl Protein | ENSP00000218176 | ||||||||||||
InnateDB Gene | IDBG-64948 (KCND1) | ||||||||||||
Protein Structure | |||||||||||||
UniProt Annotation | |||||||||||||
Function | Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. | ||||||||||||
Subcellular Localization | Membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}. | ||||||||||||
Disease Associations | |||||||||||||
Tissue Specificity | Widely expressed. Highly expressed in brain, in particular in cerebellum and thalamus; detected at lower levels in the other parts of the brain. {ECO:0000269PubMed:10729221}. | ||||||||||||
Comments | |||||||||||||
Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||
PDB ID | |||||||||||||
InterPro |
IPR000210
BTB/POZ-like IPR003091 Potassium channel IPR003131 Potassium channel tetramerisation-type BTB domain IPR003968 Potassium channel, voltage dependent, Kv IPR003971 Potassium channel, voltage dependent, Kv9 IPR003974 Potassium channel, voltage dependent, Kv3 IPR003975 Potassium channel, voltage dependent, Kv4 IPR004054 Potassium channel, voltage dependent, Kv4.1 IPR005821 Ion transport domain IPR011333 BTB/POZ fold IPR013099 Two pore domain potassium channel domain IPR021645 Shal-type voltage-gated potassium channels IPR024587 Potassium channel, voltage dependent, Kv4, C-terminal |
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PFAM |
PF02214
PF00520 PF07885 PF11601 PF11879 |
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PRINTS |
PR00169
PR01491 PR01494 PR01498 PR01497 PR01516 |
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PIRSF | |||||||||||||
SMART |
SM00225
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TIGRFAMs | |||||||||||||
Post-translational Modifications | |||||||||||||
Modification | |||||||||||||
Cross-References | |||||||||||||
SwissProt | Q9NSA2 | ||||||||||||
PhosphoSite | PhosphoSite-Q9NSA2 | ||||||||||||
TrEMBL | A6NEF1 | ||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 3750 | ||||||||||||
UniGene | Hs.55276 | ||||||||||||
RefSeq | NP_004970 | ||||||||||||
HUGO | HGNC:6237 | ||||||||||||
OMIM | 300281 | ||||||||||||
CCDS | CCDS14314 | ||||||||||||
HPRD | 02233 | ||||||||||||
IMGT | |||||||||||||
EMBL | AB021865 AF166003 AF166004 AF166005 AF166006 AF207550 AJ005898 AK094431 AK315092 BC045659 CH471224 | ||||||||||||
GenPept | AAF65516 AAF65617 AAH45659 BAA96454 BAG37557 BAG52865 CAA06755 EAW50720 EAW50721 | ||||||||||||