InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KCND1

Summary

InnateDB Gene

IDBG-64948.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCND1

Gene Name

potassium voltage-gated channel, Shal-related subfamily, member 1

Synonyms

KV4.1

Species

Homo sapiens

Ensembl Gene

ENSG00000102057

Encoded Proteins

IDBP-64950

potassium voltage-gated channel, Shal-related subfamily, member 1

IDBP-64952

potassium voltage-gated channel, Shal-related subfamily, member 1

IDBP-371067

potassium voltage-gated channel, Shal-related subfamily, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This gene is expressed at moderate levels in all tissues analyzed, with lower levels in skeletal muscle. [provided by RefSeq, Jul 2008]
This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:48961378-48971569

Strand

Reverse strand

Band

p11.23

Transcripts

ENST00000218176	ENSP00000218176
ENST00000376477	ENSP00000365660
ENST00000419374	ENSP00000413989

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006811	ion transport
GO:0007268	synaptic transmission
GO:0034765	regulation of ion transmembrane transport
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005575	cellular_component
GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000009731

View Gene Order

ENSBTAG00000009024

Not yet available

Pathways

NETPATH

REACTOME

REACT_75770

Voltage gated Potassium channels pathway

REACT_13685

Neuronal System pathway

REACT_75908

Potassium Channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q9NSA2

TrEMBL

A6NEF1

UniProt Splice Variant

Entrez Gene

3750

UniGene

Hs.55276

RefSeq

NM_004979

HUGO

HGNC:6237

OMIM

300281

CCDS

CCDS14314

HPRD

IMGT

EMBL

AB021865 AF166003 AF166004 AF166005 AF166006 AF207550 AJ005898 AK094431 AK315092 BC045659 CH471224

GenPept

AAF65516 AAF65617 AAH45659 BAA96454 BAG37557 BAG52865 CAA06755 EAW50720 EAW50721

RNA Seq Atlas

3750