InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WAC

Summary

InnateDB Protein

IDBP-65596.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WAC

Protein Name

WW domain containing adaptor with coiled-coil

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000346986

InnateDB Gene

IDBG-65590 (WAC)

Protein Structure

UniProt Annotation

Function

Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway. {ECO:0000269PubMed:21329877, ECO:0000269PubMed:22354037}.

Subcellular Localization

Nucleus speckle {ECO:0000250}. Nucleus {ECO:0000269PubMed:21329877}. Note=In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000993	RNA polymerase II core binding
GO:0003682	chromatin binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0010390	histone monoubiquitination
GO:0016239	positive regulation of macroautophagy
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0044783	G1 DNA damage checkpoint
GO:0045893	positive regulation of transcription, DNA-templated
GO:0071894	histone H2B conserved C-terminal lysine ubiquitination