Homo sapiens Protein: ABCA8
Summary
InnateDB Protein IDBP-65997.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABCA8
Protein Name ATP-binding cassette, sub-family A (ABC1), member 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000269080
InnateDB Gene IDBG-65993 (ABCA8)
Protein Structure
UniProt Annotation
Function ATP-dependent lipophilic drug transporter. {ECO:0000269PubMed:12379217}.
Subcellular Localization Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Widely expressed with higher expression in heart, skeletal muscle and liver. {ECO:0000269PubMed:12379217}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
Biological Process
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00005
PRINTS
PIRSF
SMART SM00382
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O94911
PhosphoSite PhosphoSite-O94911
TrEMBL K7ELK9
UniProt Splice Variant
Entrez Gene 10351
UniGene Hs.606204
RefSeq NP_009099
HUGO HGNC:38
OMIM 612505
CCDS CCDS11680
HPRD 09790
IMGT
EMBL AB020629 AC005922 AC015844 BC024003 BC047765 BC094689 BC130280 CH471099
GenPept AAH24003 AAH47765 AAH94689 AAI30281 BAA74845 EAW89068 EAW89069