InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BAMBI

Summary

InnateDB Protein

IDBP-66017.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BAMBI

Protein Name

BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)

Synonyms

NMA;

Species

Homo sapiens

Ensembl Protein

ENSP00000364683

InnateDB Gene

IDBG-66015 (BAMBI)

Protein Structure

UniProt Annotation

Function

Negatively regulates TGF-beta signaling.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005109	frizzled binding
GO:0005114	type II transforming growth factor beta receptor binding

Biological Process

GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0008360	regulation of cell shape
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0016477	cell migration
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032092	positive regulation of protein binding
GO:0035413	positive regulation of catenin import into nucleus
GO:0045893	positive regulation of transcription, DNA-templated
GO:0090263	positive regulation of canonical Wnt signaling pathway