Homo sapiens Gene: BAMBI
Summary
InnateDB Gene IDBG-66015.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BAMBI
Gene Name BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)
Synonyms NMA;
Species Homo sapiens
Ensembl Gene ENSG00000095739
Encoded Proteins
BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)
BMP and activin membrane-bound inhibitor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:28677342-28682939
Strand Forward strand
Band p12.1
Transcripts
ENST00000375533 ENSP00000364683
ENST00000497699
ENST00000622753 ENSP00000482033
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005109 frizzled binding
GO:0005114 type II transforming growth factor beta receptor binding
Biological Process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0008360 regulation of cell shape
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0016477 cell migration
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032092 positive regulation of protein binding
GO:0035413 positive regulation of catenin import into nucleus
GO:0045893 positive regulation of transcription, DNA-templated
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
SMAD4 MH2 Domain Mutants in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Downregulation of TGF-beta receptor signaling pathway
TGFBR1 KD Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
TGF-beta receptor signaling activates SMADs pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
KEGG
Wnt signaling pathway pathway
TGF-beta signaling pathway pathway
INOH
BMP2 signaling pathway
PID BIOCARTA
PID NCI
BMP receptor signaling
TGF-beta receptor signaling
Cross-References
SwissProt Q13145
TrEMBL
UniProt Splice Variant
Entrez Gene 25805
UniGene Hs.533336 Hs.703618
RefSeq NM_012342
HUGO HGNC:30251
OMIM 604444
CCDS CCDS7162
HPRD
IMGT
EMBL AL161936 BC019252 BT006820 U23070 U29188 U29189
GenPept AAC50435 AAH19252 AAP35466 AAR02414 CAC16002
RNA Seq Atlas 25805