InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BAMBI

Summary

InnateDB Gene

IDBG-66015.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BAMBI

Gene Name

BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)

Synonyms

NMA

Species

Homo sapiens

Ensembl Gene

ENSG00000095739

Encoded Proteins

IDBP-66017

BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)

IDBP-811121

BMP and activin membrane-bound inhibitor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:28677342-28682939

Strand

Forward strand

Band

p12.1

Transcripts

ENST00000375533	ENSP00000364683
ENST00000497699
ENST00000622753	ENSP00000482033

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005109	frizzled binding
GO:0005114	type II transforming growth factor beta receptor binding

Biological Process

GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0008360	regulation of cell shape
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0016477	cell migration
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032092	positive regulation of protein binding
GO:0035413	positive regulation of catenin import into nucleus
GO:0045893	positive regulation of transcription, DNA-templated
GO:0090263	positive regulation of canonical Wnt signaling pathway