InnateDB Protein
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IDBP-66816.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IL1RN
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Protein Name
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interleukin 1 receptor antagonist
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Synonyms
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DIRA; ICIL-1RA; IL-1ra; IL-1ra3; IL-1RN; IL1F3; IL1RA; IRAP; MVCD4;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000354816
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InnateDB Gene
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IDBG-66814 (IL1RN)
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Protein Structure
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Function |
Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. {ECO:0000269PubMed:7775431}.
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Subcellular Localization |
Isoform 1: Secreted.Isoform 2: Cytoplasm.Isoform 3: Cytoplasm.Isoform 4: Cytoplasm.
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Disease Associations |
Microvascular complications of diabetes 4 (MVCD4) [MIM:612628]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end- stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Interleukin 1 receptor antagonist deficiency (DIRA) [MIM:612852]: A rare autoinflammatory disease of skin and bone resulting in sterile multifocal osteomyelitis, periostitis, and pustulosis from birth. The term autoinflammatory disease describes a group of disorders characterized by attacks of seemingly unprovoked inflammation without significant levels of autoantibodies and autoreactive T-cells. {ECO:0000269PubMed:19494218}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
The intracellular form of IL1RN is predominantly expressed in epithelial cells.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005149
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interleukin-1 receptor binding
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GO:0005150
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interleukin-1, Type I receptor binding
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GO:0005151
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interleukin-1, Type II receptor binding
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GO:0005152
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interleukin-1 receptor antagonist activity
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GO:0045352
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interleukin-1 Type I receptor antagonist activity
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GO:0045353
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interleukin-1 Type II receptor antagonist activity
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Biological Process |
GO:0001960
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negative regulation of cytokine-mediated signaling pathway
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GO:0006953
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acute-phase response
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GO:0006955
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immune response
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GO:0034115
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negative regulation of heterotypic cell-cell adhesion
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GO:0051384
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response to glucocorticoid
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GO:2000660
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negative regulation of interleukin-1-mediated signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR000975
Interleukin-1 family
IPR003297
Interleukin-1 receptor antagonist / Interleukin-36
IPR008996
Cytokine, IL-1-like
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PFAM |
PF00340
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PRINTS |
PR00264
PR01360
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P18510
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PhosphoSite |
PhosphoSite-
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TrEMBL |
A0A024R528
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UniProt Splice Variant |
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Entrez Gene |
3557
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UniGene |
Hs.81134
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RefSeq |
NP_776215
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HUGO |
HGNC:6000
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OMIM |
147679
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CCDS |
CCDS2115
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HPRD |
00978
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IMGT |
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EMBL |
AC024704
AF043143
AK290898
AK290926
AY196903
BC009745
BN000002
CH471217
M55646
M63099
U65590
X52015
X53296
X64532
X84348
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GenPept |
AAA59138
AAB41943
AAB92268
AAB92269
AAB92270
AAC39672
AAH09745
AAN87150
AAX93278
BAF83587
BAF83615
CAA36262
CAA37386
CAA45832
CAA59087
CAD29879
EAW73621
EAW73623
EAW73624
EAW73625
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