Version 5.4
Homo sapiens Gene: IL1RN
Summary
InnateDB Gene IDBG-66814.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL1RN
Gene Name interleukin 1 receptor antagonist
Synonyms DIRA; ICIL-1RA; IL-1ra; IL-1ra3; IL-1RN; IL1F3; IL1RA; IRAP; MVCD4
Species Homo sapiens
Ensembl Gene ENSG00000136689
Encoded Proteins
IDBP-66816
interleukin 1 receptor antagonist
IDBP-66818
interleukin 1 receptor antagonist
IDBP-66820
interleukin 1 receptor antagonist
IDBP-294718
interleukin 1 receptor antagonist
IDBP-294716
interleukin 1 receptor antagonist
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:113107214-113134016
Strand Forward strand
Band q14.1
Transcripts
ENST00000361779 ENSP00000354816
ENST00000259206 ENSP00000259206
ENST00000354115 ENSP00000329072
ENST00000409930 ENSP00000387173
ENST00000409052 ENSP00000387210
ENST00000465812
ENST00000463073
ENST00000486167
ENST00000472292
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005149 interleukin-1 receptor binding
GO:0005150 interleukin-1, Type I receptor binding
GO:0005151 interleukin-1, Type II receptor binding
GO:0005152 interleukin-1 receptor antagonist activity
GO:0045352 interleukin-1 Type I receptor antagonist activity
GO:0045353 interleukin-1 Type II receptor antagonist activity
Biological Process
GO:0001660 fever generation
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0002439 chronic inflammatory response to antigenic stimulus
GO:0006629 lipid metabolic process
GO:0006953 acute-phase response
GO:0006955 immune response
GO:0007565 female pregnancy
GO:0007613 memory
GO:0010243 response to organonitrogen compound
GO:0014050 negative regulation of glutamate secretion
GO:0014070 response to organic cyclic compound
GO:0014823 response to activity
GO:0019233 sensory perception of pain
GO:0019752 carboxylic acid metabolic process
GO:0030073 insulin secretion
GO:0030336 negative regulation of cell migration
GO:0032496 response to lipopolysaccharide
GO:0034115 negative regulation of heterotypic cell-cell adhesion
GO:0042493 response to drug
GO:0042594 response to starvation
GO:0043066 negative regulation of apoptotic process
GO:0043507 positive regulation of JUN kinase activity
GO:0045837 negative regulation of membrane potential
GO:0051384 response to glucocorticoid
GO:0070555 response to interleukin-1
GO:0070670 response to interleukin-4
GO:0071874 cellular response to norepinephrine stimulus
GO:2000660 negative regulation of interleukin-1-mediated signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0031982 vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026981
View Gene Order
ENSBTAG00000019665
Not yet available
Pathways
NETPATH
NetPath_13
IL1 pathway
REACTOME
REACT_22442
Interleukin-1 signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
KEGG
INOH
PID NCI
il1pathway
IL1-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.701610 Hs.734203 Hs.81134
RefSeq NM_000577 NM_173841 NM_173842 NM_173843 XM_005263661 XM_006712497
HUGO
OMIM
CCDS CCDS2113 CCDS2114 CCDS2115 CCDS46396
HPRD 00978
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca