InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL1RN

Summary

InnateDB Protein

IDBP-66818.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL1RN

Protein Name

interleukin 1 receptor antagonist

Synonyms

DIRA; ICIL-1RA; IL-1ra; IL-1ra3; IL-1RN; IL1F3; IL1RA; IRAP; MVCD4;

Species

Homo sapiens

Ensembl Protein

ENSP00000259206

InnateDB Gene

IDBG-66814 (IL1RN)

Protein Structure

UniProt Annotation

Function

Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. {ECO:0000269PubMed:7775431}.

Subcellular Localization

Isoform 1: Secreted.Isoform 2: Cytoplasm.Isoform 3: Cytoplasm.Isoform 4: Cytoplasm.

Disease Associations

Microvascular complications of diabetes 4 (MVCD4) [MIM:612628]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end- stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Interleukin 1 receptor antagonist deficiency (DIRA) [MIM:612852]: A rare autoinflammatory disease of skin and bone resulting in sterile multifocal osteomyelitis, periostitis, and pustulosis from birth. The term autoinflammatory disease describes a group of disorders characterized by attacks of seemingly unprovoked inflammation without significant levels of autoantibodies and autoreactive T-cells. {ECO:0000269PubMed:19494218}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

The intracellular form of IL1RN is predominantly expressed in epithelial cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005149	interleukin-1 receptor binding
GO:0005150	interleukin-1, Type I receptor binding
GO:0005151	interleukin-1, Type II receptor binding
GO:0005152	interleukin-1 receptor antagonist activity
GO:0045352	interleukin-1 Type I receptor antagonist activity
GO:0045353	interleukin-1 Type II receptor antagonist activity

Biological Process

GO:0001660	fever generation
GO:0001960	negative regulation of cytokine-mediated signaling pathway
GO:0002439	chronic inflammatory response to antigenic stimulus
GO:0006629	lipid metabolic process
GO:0006953	acute-phase response
GO:0006955	immune response
GO:0007565	female pregnancy
GO:0007613	memory
GO:0010243	response to organonitrogen compound
GO:0014050	negative regulation of glutamate secretion
GO:0014070	response to organic cyclic compound
GO:0014823	response to activity
GO:0019233	sensory perception of pain
GO:0019752	carboxylic acid metabolic process
GO:0030073	insulin secretion
GO:0030336	negative regulation of cell migration
GO:0032496	response to lipopolysaccharide
GO:0034115	negative regulation of heterotypic cell-cell adhesion
GO:0042493	response to drug
GO:0042594	response to starvation
GO:0043066	negative regulation of apoptotic process
GO:0043507	positive regulation of JUN kinase activity
GO:0045837	negative regulation of membrane potential
GO:0051384	response to glucocorticoid
GO:0070555	response to interleukin-1
GO:0070670	response to interleukin-4
GO:0071874	cellular response to norepinephrine stimulus
GO:2000660	negative regulation of interleukin-1-mediated signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0031982	vesicle
GO:0070062	extracellular vesicular exosome