Version 5.4
Homo sapiens Protein: NECAB3
Summary
InnateDB Protein IDBP-66929.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NECAB3
Protein Name N-terminal EF-hand calcium binding protein 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000246190
InnateDB Gene IDBG-66925 (NECAB3)
Protein Structure
UniProt Annotation
Function Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation of beta- amyloid. {ECO:0000269PubMed:10833507}.
Subcellular Localization Golgi apparatus {ECO:0000269PubMed:10833507, ECO:0000269PubMed:14697346}.
Disease Associations
Tissue Specificity Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas. {ECO:0000269PubMed:10833507, ECO:0000269PubMed:12044471}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0009306 protein secretion
GO:0019538 protein metabolic process
GO:0042984 regulation of amyloid precursor protein biosynthetic process
Cellular Component
GO:0000137 Golgi cis cisterna
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID
InterPro IPR002048 EF-hand domain
IPR007138 Antibiotic biosynthesis monooxygenase-like domain
IPR011008 Dimeric alpha-beta barrel
PFAM PF00036
PF13202
PF13405
PF03992
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96P71
PhosphoSite PhosphoSite-Q96P71
TrEMBL H0UI92
UniProt Splice Variant
Entrez Gene 63941
UniGene Hs.629982
RefSeq NP_112509
HUGO HGNC:15851
OMIM 612478
CCDS CCDS42866
HPRD 07168
IMGT
EMBL AB039947 AF193759 AF409141 AK023706 AK291895 AL121906 BC047673 CH471077
GenPept AAG28415 AAH47673 AAL01118 BAB14649 BAB16413 BAF84584 CAI22127 CAI22128 CAI22129 EAW76302 EAW76304 EAW76305 EAW76308

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca