Homo sapiens Protein: ZEB1
Summary
InnateDB Protein IDBP-66947.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZEB1
Protein Name zinc finger E-box binding homeobox 1
Synonyms AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3; TCF8; ZFHEP; ZFHX1A;
Species Homo sapiens
Ensembl Protein ENSP00000354487
InnateDB Gene IDBG-66941 (ZEB1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 21 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0070888 E-box binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006955 immune response
GO:0007389 pattern specification process
GO:0007417 central nervous system development
GO:0008283 cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010464 regulation of mesenchymal cell proliferation
GO:0014823 response to activity
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0030857 negative regulation of epithelial cell differentiation
GO:0030900 forebrain development
GO:0031667 response to nutrient levels
GO:0033081 regulation of T cell differentiation in thymus
GO:0045666 positive regulation of neuron differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048513 organ development
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048598 embryonic morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048752 semicircular canal morphogenesis
GO:0051150 regulation of smooth muscle cell differentiation
GO:0051216 cartilage development
GO:0071230 cellular response to amino acid stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090103 cochlea morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001356 Homeobox domain
IPR007087 Zinc finger, C2H2
IPR009057 Homeodomain-like
IPR015880 Zinc finger, C2H2-like
PFAM PF00046
PF00096
PRINTS
PIRSF
SMART SM00389
SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P37275
PhosphoSite PhosphoSite-P37275
TrEMBL F6TDF5
UniProt Splice Variant
Entrez Gene 6935
UniGene Hs.733308
RefSeq NP_001167567
HUGO HGNC:11642
OMIM 189909
CCDS CCDS53505
HPRD 01798
IMGT
EMBL AK091478 AK296244 AK300830 AL117340 AL158080 AL161935 AL355148 BC112392 CH471072 D15050 M81699 U12170
GenPept AAA20602 AAI12393 BAA03646 BAC03673 BAG58962 BAG62481 CAH74132 CAI12550 CAI15108 CAI17320 EAW85989