InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ZEB1

Summary

InnateDB Gene

IDBG-66941.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZEB1

Gene Name

zinc finger E-box binding homeobox 1

Synonyms

AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3; TCF8; ZFHEP; ZFHX1A

Species

Homo sapiens

Ensembl Gene

ENSG00000148516

Encoded Proteins

IDBP-66947

zinc finger E-box binding homeobox 1

IDBP-66949

zinc finger E-box binding homeobox 1

IDBP-371873

zinc finger E-box binding homeobox 1

IDBP-371893

zinc finger E-box binding homeobox 1

IDBP-371895

zinc finger E-box binding homeobox 1

IDBP-596286

zinc finger E-box binding homeobox 1

IDBP-598610

zinc finger E-box binding homeobox 1

IDBP-595879

zinc finger E-box binding homeobox 1

IDBP-599143

zinc finger E-box binding homeobox 1

IDBP-584431

zinc finger E-box binding homeobox 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:31318495-31529814

Strand

Forward strand

Band

p11.22

Transcripts

ENST00000361642	ENSP00000354487
ENST00000320985	ENSP00000319248
ENST00000437844	ENSP00000405958
ENST00000424869	ENSP00000415961
ENST00000446923	ENSP00000391612
ENST00000488625
ENST00000493835
ENST00000560196
ENST00000542879
ENST00000561304
ENST00000559858
ENST00000560721	ENSP00000452787
ENST00000558440	ENSP00000453970
ENST00000542815	ENSP00000444891
ENST00000558863
ENST00000561212	ENSP00000453559
ENST00000558655
ENST00000561061
ENST00000559496
ENST00000559476	ENSP00000453674
ENST00000557827
ENST00000558832
ENST00000560909
ENST00000606671
ENST00000606161

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	21 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006955	immune response
GO:0007389	pattern specification process
GO:0007417	central nervous system development
GO:0008283	cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0010464	regulation of mesenchymal cell proliferation
GO:0014823	response to activity
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0030857	negative regulation of epithelial cell differentiation
GO:0030900	forebrain development
GO:0031667	response to nutrient levels
GO:0033081	regulation of T cell differentiation in thymus
GO:0045666	positive regulation of neuron differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048513	organ development
GO:0048596	embryonic camera-type eye morphogenesis
GO:0048598	embryonic morphogenesis
GO:0048704	embryonic skeletal system morphogenesis
GO:0048752	semicircular canal morphogenesis
GO:0051150	regulation of smooth muscle cell differentiation
GO:0051216	cartilage development
GO:0071230	cellular response to amino acid stimulus
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0090103	cochlea morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024238

View Gene Order

ENSBTAG00000020053

Not yet available

Pathways

NETPATH

NetPath_7

TGF_beta_Receptor pathway

REACTOME

KEGG

INOH

PID NCI

ilk_pathway

Integrin-linked kinase signaling

Cross-References

SwissProt

P37275

TrEMBL

F6TDF5

UniProt Splice Variant

Entrez Gene

6935

UniGene

Hs.124503 Hs.593418 Hs.733248 Hs.733308

RefSeq

NM_001174096 NM_001128128 NM_001174093 NM_001174094 NM_001174095 NM_030751 XM_005252575 XM_005252576 XM_006717497 XM_006717498 XM_006717499

HUGO

HGNC:11642

OMIM

189909

CCDS

CCDS53505 CCDS44370 CCDS53506 CCDS53507 CCDS7169

HPRD

01798

IMGT

EMBL

AK091478 AK296244 AK300830 AL117340 AL158080 AL161935 AL355148 BC112392 CH471072 D15050 M81699 U12170

GenPept

AAA20602 AAI12393 BAA03646 BAC03673 BAG58962 BAG62481 CAH74132 CAI12550 CAI15108 CAI17320 EAW85989

RNA Seq Atlas

100996668 6935