Homo sapiens Gene: ZEB1
Summary
InnateDB Gene IDBG-66941.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZEB1
Gene Name zinc finger E-box binding homeobox 1
Synonyms AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3; TCF8; ZFHEP; ZFHX1A;
Species Homo sapiens
Ensembl Gene ENSG00000148516
Encoded Proteins
zinc finger E-box binding homeobox 1
zinc finger E-box binding homeobox 1
zinc finger E-box binding homeobox 1
zinc finger E-box binding homeobox 1
zinc finger E-box binding homeobox 1
zinc finger E-box binding homeobox 1
zinc finger E-box binding homeobox 1
zinc finger E-box binding homeobox 1
zinc finger E-box binding homeobox 1
zinc finger E-box binding homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:31318495-31529814
Strand Forward strand
Band p11.22
Transcripts
ENST00000361642 ENSP00000354487
ENST00000320985 ENSP00000319248
ENST00000437844 ENSP00000405958
ENST00000424869 ENSP00000415961
ENST00000446923 ENSP00000391612
ENST00000488625
ENST00000493835
ENST00000560196
ENST00000542879
ENST00000561304
ENST00000559858
ENST00000560721 ENSP00000452787
ENST00000558440 ENSP00000453970
ENST00000542815 ENSP00000444891
ENST00000558863
ENST00000561212 ENSP00000453559
ENST00000558655
ENST00000561061
ENST00000559496
ENST00000559476 ENSP00000453674
ENST00000557827
ENST00000558832
ENST00000560909
ENST00000606671
ENST00000606161
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 21 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0070888 E-box binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006955 immune response
GO:0007389 pattern specification process
GO:0007417 central nervous system development
GO:0008283 cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010464 regulation of mesenchymal cell proliferation
GO:0014823 response to activity
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0030857 negative regulation of epithelial cell differentiation
GO:0030900 forebrain development
GO:0031667 response to nutrient levels
GO:0033081 regulation of T cell differentiation in thymus
GO:0045666 positive regulation of neuron differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048513 organ development
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048598 embryonic morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048752 semicircular canal morphogenesis
GO:0051150 regulation of smooth muscle cell differentiation
GO:0051216 cartilage development
GO:0071230 cellular response to amino acid stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090103 cochlea morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TGF_beta_Receptor pathway
REACTOME
KEGG
INOH
PID BIOCARTA
Sumoylation as a mechanism to modulate ctbp-dependent gene responses [Biocarta view]
PID NCI
Integrin-linked kinase signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.124503 Hs.593418 Hs.733248 Hs.733308
RefSeq NM_001128128 NM_001174093 NM_001174094 NM_001174095 NM_001174096 NM_030751 XM_005252575 XM_005252576 XM_006717497 XM_006717498 XM_006717499
HUGO
OMIM
CCDS CCDS44370 CCDS53505 CCDS53506 CCDS53507 CCDS7169
HPRD 01798
IMGT
EMBL
GenPept
RNA Seq Atlas