Homo sapiens Protein: ZEB1
Summary
InnateDB Protein IDBP-66949.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZEB1
Protein Name zinc finger E-box binding homeobox 1
Synonyms AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3; TCF8; ZFHEP; ZFHX1A;
Species Homo sapiens
Ensembl Protein ENSP00000319248
InnateDB Gene IDBG-66941 (ZEB1)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. {ECO:0000269PubMed:19935649, ECO:0000269PubMed:20175752, ECO:0000269PubMed:20418909}.
Subcellular Localization Nucleus {ECO:0000269PubMed:20418909}.
Disease Associations Corneal dystrophy, posterior polymorphous, 3 (PPCD3) [MIM:609141]: A subtype of posterior corneal dystrophy, a disease characterized by alterations of Descemet membrane presenting as vesicles, opacities or band-like lesions on slit-lamp examination and specular microscopy. Affected patient typically are asymptomatic. {ECO:0000269PubMed:16252232}. Note=The disease is caused by mutations affecting the gene represented in this entry.Corneal dystrophy, Fuchs endothelial, 6 (FECD6) [MIM:613270]: A corneal disease caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition. {ECO:0000269PubMed:20036349}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Colocalizes with SMARCA4/BRG1 in E-cadherin- negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas. {ECO:0000269PubMed:20418909}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 21 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0070888 E-box binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006955 immune response
GO:0008283 cell proliferation
GO:0045666 positive regulation of neuron differentiation
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001356 Homeobox domain
IPR007087 Zinc finger, C2H2
IPR009057 Homeodomain-like
IPR015880 Zinc finger, C2H2-like
PFAM PF00046
PF00096
PRINTS
PIRSF
SMART SM00389
SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P37275
PhosphoSite PhosphoSite-P37275
TrEMBL
UniProt Splice Variant
Entrez Gene 6935
UniGene Hs.733308
RefSeq NP_110378
HUGO HGNC:11642
OMIM 189909
CCDS CCDS7169
HPRD 01798
IMGT
EMBL AK091478 AK296244 AK300830 AL117340 AL158080 AL161935 AL355148 BC112392 CH471072 D15050 M81699 U12170
GenPept AAA20602 AAI12393 BAA03646 BAC03673 BAG58962 BAG62481 CAH74132 CAI12550 CAI15108 CAI17320 EAW85989