InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PSMD2

Summary

InnateDB Protein

IDBP-67754.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PSMD2

Protein Name

proteasome (prosome, macropain) 26S subunit, non-ATPase, 2

Synonyms

P97; RPN1; S2; TRAP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000310129

InnateDB Gene

IDBG-67752 (PSMD2)

Protein Structure

UniProt Annotation

Function

Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.

Subcellular Localization

Disease Associations

Tissue Specificity

Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 219 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	219 [view]
Protein-Protein	217 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0030234	enzyme regulator activity

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000209	protein polyubiquitination
GO:0000278	mitotic cell cycle
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006521	regulation of cellular amino acid metabolic process
GO:0006915	apoptotic process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0042176	regulation of protein catabolic process
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0044281	small molecule metabolic process
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

Cellular Component

GO:0000502	proteasome complex
GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0005838	proteasome regulatory particle
GO:0016020	membrane
GO:0022624	proteasome accessory complex
GO:0070062	extracellular vesicular exosome