InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.49327

Summary

InnateDB Protein

IDBP-679928.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.49327

Protein Name

alpha-actinin-2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000012786

InnateDB Gene

IDBG-628557 (BT.49327)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0030274	LIM domain binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0030375	thyroid hormone receptor coactivator activity
GO:0031432	titin binding
GO:0042802	identical protein binding
GO:0044325	ion channel binding
GO:0046983	protein dimerization activity
GO:0051015	actin filament binding
GO:0051373	FATZ binding
GO:0070080	titin Z domain binding

Biological Process

GO:0006936	muscle contraction
GO:0030035	microspike assembly
GO:0042391	regulation of membrane potential
GO:0043267	negative regulation of potassium ion transport
GO:0043268	positive regulation of potassium ion transport
GO:0048041	focal adhesion assembly
GO:0051289	protein homotetramerization
GO:1901017	negative regulation of potassium ion transmembrane transporter activity
GO:1901018	positive regulation of potassium ion transmembrane transporter activity
GO:2000009	negative regulation of protein localization to cell surface
GO:2000273	positive regulation of receptor activity
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005925	focal adhesion
GO:0030017	sarcomere
GO:0030018	Z disc
GO:0030175	filopodium
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001715 Calponin homology domain
IPR002017 Spectrin repeat
IPR002048 EF-hand domain
IPR014837 EF-hand, Ca insensitive
IPR018159 Spectrin/alpha-actinin
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM