Bos taurus Gene: BT.49327 | |||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-628557.3 | ||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||
Gene Symbol | BT.49327 | ||||||||||||||||||||||||||||||
Gene Name | alpha-actinin-2 | ||||||||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000009696 | ||||||||||||||||||||||||||||||
Encoded Proteins |
alpha-actinin-2
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Protein Structure | |||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077522:
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. [provided by RefSeq, Jul 2008] Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013] |
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Gene Information | |||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||
Genomic Location | Chromosome 28:9403202-9450916 | ||||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||||
Band | |||||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||
REACTOME |
Platelet degranulation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Ras activation uopn Ca2+ infux through NMDA receptor pathway
CREB phosphorylation through the activation of Ras pathway
CREB phosphorylation through the activation of CaMKII pathway
Unblocking of NMDA receptor, glutamate binding and activation pathway
Nephrin interactions pathway
Striated Muscle Contraction pathway
Cell-Cell communication pathway
Neuronal System pathway
Platelet activation, signaling and aggregation pathway
Post NMDA receptor activation events pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
Transmission across Chemical Synapses pathway
Muscle contraction pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Hemostasis pathway
Platelet degranulation pathway
Hemostasis pathway
Nephrin interactions pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Striated Muscle Contraction pathway
Ras activation uopn Ca2+ infux through NMDA receptor pathway
CREB phosphorylation through the activation of Ras pathway
CREB phosphorylation through the activation of CaMKII pathway
Platelet activation, signaling and aggregation pathway
Post NMDA receptor activation events pathway
Muscle contraction pathway
Neuronal System pathway
Unblocking of NMDA receptor, glutamate binding and activation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Transmission across Chemical Synapses pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
Cell-Cell communication pathway
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KEGG |
Regulation of actin cytoskeleton pathway
Adherens junction pathway
Leukocyte transendothelial migration pathway
Tight junction pathway
Focal adhesion pathway
Systemic lupus erythematosus pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Amoebiasis pathway
Tight junction pathway
Regulation of actin cytoskeleton pathway
Adherens junction pathway
Leukocyte transendothelial migration pathway
Focal adhesion pathway
Systemic lupus erythematosus pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Amoebiasis pathway
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INOH | |||||||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||
UniGene | Bt.49327 | ||||||||||||||||||||||||||||||
RefSeq | NM_001034635 | ||||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||||