InnateDB Protein
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IDBP-680071.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CNOT7
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Protein Name
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CCR4-NOT transcription complex subunit 7
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000024009
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InnateDB Gene
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IDBG-628698 (CNOT7)
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Protein Structure
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Function |
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for miRNA-mediated mRNA deadenylation. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
36 [view]
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Molecular Function |
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Biological Process |
GO:0000289
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nuclear-transcribed mRNA poly(A) tail shortening
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GO:0000290
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deadenylation-dependent decapping of nuclear-transcribed mRNA
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GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006417
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regulation of translation
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GO:0008284
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positive regulation of cell proliferation
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GO:0008285
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negative regulation of cell proliferation
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GO:0031047
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gene silencing by RNA
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GO:0033962
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cytoplasmic mRNA processing body assembly
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GO:0043928
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exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0060213
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positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
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GO:0090305
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nucleic acid phosphodiester bond hydrolysis
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GO:0090503
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RNA phosphodiester bond hydrolysis, exonucleolytic
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GO:1900153
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positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
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Cellular Component |
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PDB ID |
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InterPro |
IPR006941
Ribonuclease CAF1
IPR012337
Ribonuclease H-like domain
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PFAM |
PF04857
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3ZC01
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
508055
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UniGene |
Bt.99842
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RefSeq |
NP_001029484
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC103000
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GenPept |
AAI03001
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