InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TNKS

Summary

InnateDB Protein

IDBP-680223.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNKS

Protein Name

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000001917

InnateDB Gene

IDBG-628743 (TNKS)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003950	NAD+ ADP-ribosyltransferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006471	protein ADP-ribosylation
GO:0016055	Wnt signaling pathway
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0032212	positive regulation of telomere maintenance via telomerase
GO:0043392	negative regulation of DNA binding
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051225	spindle assembly
GO:0070198	protein localization to chromosome, telomeric region
GO:0070212	protein poly-ADP-ribosylation
GO:0070213	protein auto-ADP-ribosylation
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0000784	nuclear chromosome, telomeric region
GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001660 Sterile alpha motif domain
IPR002110 Ankyrin repeat
IPR011510 Sterile alpha motif, type 2
IPR012317 Poly(ADP-ribose) polymerase, catalytic domain
IPR013761 Sterile alpha motif/pointed domain
IPR020683 Ankyrin repeat-containing domain
IPR021129 Sterile alpha motif, type 1

PFAM