InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MERTK

Summary

InnateDB Protein

IDBP-680248.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MERTK

Protein Name

c-mer proto-oncogene tyrosine kinase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000007664

InnateDB Gene

IDBG-628865 (MERTK)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001779	natural killer cell differentiation
GO:0006468	protein phosphorylation
GO:0006909	phagocytosis
GO:0007283	spermatogenesis
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030168	platelet activation
GO:0032940	secretion by cell
GO:0034446	substrate adhesion-dependent cell spreading
GO:0043277	apoptotic cell clearance
GO:0043491	protein kinase B signaling
GO:0050766	positive regulation of phagocytosis
GO:0051250	negative regulation of lymphocyte activation
GO:0060041	retina development in camera-type eye
GO:0060068	vagina development

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016028	rhabdomere

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00041
PF01108
PF07679

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00409
SM00060
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt