InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MERTK

Summary

InnateDB Gene

IDBG-628865.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MERTK

Gene Name

tyrosine-protein kinase Mer precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005828

Encoded Proteins

IDBP-680248

c-mer proto-oncogene tyrosine kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18083102

[Homo sapiens] MERTK is a tyrosine protein kinase, it acts with TYRO3 and AXL as pleiotropic inhibitor of the innate immune response in DCs.

PMID 23954153

[Mus musculus] Viruses engage Tyro3/Axl/Mertk (TAM) receptors in order to inhibit host type I IFN signalling.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153208:
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:332458-427685

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000007664

ENSBTAP00000007664

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001779	natural killer cell differentiation
GO:0006468	protein phosphorylation
GO:0006909	phagocytosis
GO:0007283	spermatogenesis
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030168	platelet activation
GO:0032940	secretion by cell
GO:0034446	substrate adhesion-dependent cell spreading
GO:0043277	apoptotic cell clearance
GO:0043491	protein kinase B signaling
GO:0050766	positive regulation of phagocytosis
GO:0051250	negative regulation of lymphocyte activation
GO:0060041	retina development in camera-type eye
GO:0060068	vagina development

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016028	rhabdomere

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000153208

View Gene Order

ENSMUSG00000014361

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_12051

Cell surface interactions at the vascular wall pathway

REACT_604

Hemostasis pathway

REACT_224553

Hemostasis pathway

REACT_225233

Cell surface interactions at the vascular wall pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

F1N381

UniProt Splice Variant

Entrez Gene

504429

UniGene

Bt.22026

RefSeq

NM_001192024

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02030062 DAAA02030063 DAAA02030064 DAAA02030065

GenPept

RNA Seq Atlas

504429