Version 5.4
Bos taurus Protein: BRD2
Summary
InnateDB Protein IDBP-680266.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRD2
Protein Name Bromodomain-containing protein 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000014704
InnateDB Gene IDBG-628888 (BRD2)
Protein Structure
UniProt Annotation
Function Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly (By similarity). May play a role in spermatogenesis or folliculogenesis (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Note=Detected on chromatin and nucleosomes. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0070577 lysine-acetylated histone binding
Biological Process
GO:0006334 nucleosome assembly
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0016568 chromatin modification
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001487 Bromodomain
PFAM PF00439
PRINTS PR00503
PIRSF
SMART SM00297
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q32S26
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 505358
UniGene Bt.33281
RefSeq NP_001039331
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY957499
GenPept AAY34703

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca