Version 5.4
Bos taurus Protein: CPE
Summary
InnateDB Protein IDBP-680290.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPE
Protein Name Carboxypeptidase E
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000021955
InnateDB Gene IDBG-628913 (CPE)
Protein Structure
UniProt Annotation
Function Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing.
Subcellular Localization Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0042043 neurexin family protein binding
GO:0046872 metal ion binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0003214 cardiac left ventricle morphogenesis
GO:0006508 proteolysis
GO:0030070 insulin processing
GO:0072657 protein localization to membrane
Cellular Component
GO:0005576 extracellular region
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0030658 transport vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000834 Peptidase M14, carboxypeptidase A
IPR008969 Carboxypeptidase-like, regulatory domain
PFAM PF00246
PRINTS PR00765
PIRSF
SMART SM00631
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P04836
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 280753
UniGene Bt.73670
RefSeq NP_776328
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AH012367 AH014826 BC142181 X04411
GenPept AAI42182 AAO03557 AAX84651 CAA27999

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca