InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CPE

Summary

InnateDB Gene

IDBG-628913.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CPE

Gene Name

Carboxypeptidase E

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016514

Encoded Proteins

IDBP-680290

Carboxypeptidase E

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109472:
This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:546398-697915

Strand

Forward strand

Band

Transcripts

ENSBTAT00000021955

ENSBTAP00000021955

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004180	carboxypeptidase activity
GO:0004181	metallocarboxypeptidase activity
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0042043	neurexin family protein binding
GO:0046872	metal ion binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0003214	cardiac left ventricle morphogenesis
GO:0006508	proteolysis
GO:0030070	insulin processing
GO:0072657	protein localization to membrane

Cellular Component

GO:0005576	extracellular region
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0030658	transport vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0070062	extracellular vesicular exosome