InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CDK6

Summary

InnateDB Protein

IDBP-680441.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDK6

Protein Name

cyclin-dependent kinase 6

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000053788

InnateDB Gene

IDBG-629049 (CDK6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 96 interaction(s) predicted by orthology.

Predicted by orthology
Total	96 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030332	cyclin binding

Biological Process

GO:0001954	positive regulation of cell-matrix adhesion
GO:0003323	type B pancreatic cell development
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0009615	response to virus
GO:0010468	regulation of gene expression
GO:0042063	gliogenesis
GO:0042127	regulation of cell proliferation
GO:0043697	cell dedifferentiation
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045646	regulation of erythrocyte differentiation
GO:0045668	negative regulation of osteoblast differentiation
GO:0045786	negative regulation of cell cycle
GO:0048146	positive regulation of fibroblast proliferation
GO:0050680	negative regulation of epithelial cell proliferation
GO:2000773	negative regulation of cellular senescence

Cellular Component

GO:0000307	cyclin-dependent protein kinase holoenzyme complex
GO:0001726	ruffle
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt