InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: COL1A2

Summary

InnateDB Protein

IDBP-680582.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COL1A2

Protein Name

Collagen alpha-2(I) chain

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000033771

InnateDB Gene

IDBG-629088 (COL1A2)

Protein Structure

UniProt Annotation

Function

Type I collagen is a member of group I collagen (fibrillar forming collagen).

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000255PROSITE-ProRule:PRU00793}.

Disease Associations

Tissue Specificity

Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0030674	protein binding, bridging
GO:0042802	identical protein binding
GO:0046332	SMAD binding
GO:0046872	metal ion binding
GO:0048407	platelet-derived growth factor binding

Biological Process

GO:0001501	skeletal system development
GO:0001568	blood vessel development
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007266	Rho protein signal transduction
GO:0008217	regulation of blood pressure
GO:0030199	collagen fibril organization
GO:0043589	skin morphogenesis
GO:0070208	protein heterotrimerization
GO:0071230	cellular response to amino acid stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005581	collagen trimer
GO:0005584	collagen type I
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000885 Fibrillar collagen, C-terminal
IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
IPR008160 Collagen triple helix repeat

PFAM

PF01410
PF00147
PF01391

PRINTS

PIRSF

SMART

SM00038
SM00186

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P02465