Version 5.4
Bos taurus Protein: HMGB2
Summary
InnateDB Protein IDBP-680703.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMGB2
Protein Name High mobility group protein B2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000020096
InnateDB Gene IDBG-629304 (HMGB2)
Protein Structure
UniProt Annotation
Function DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00267}. Chromosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008301 DNA binding, bending
GO:0042056 chemoattractant activity
GO:0042393 histone binding
GO:0044212 transcription regulatory region DNA binding
GO:0044822 poly(A) RNA binding
GO:0050786 RAGE receptor binding
Biological Process
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006265 DNA topological change
GO:0006288 base-excision repair, DNA ligation
GO:0006310 DNA recombination
GO:0006338 chromatin remodeling
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0032075 positive regulation of nuclease activity
GO:0033151 V(D)J recombination
GO:0043388 positive regulation of DNA binding
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045654 positive regulation of megakaryocyte differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050918 positive chemotaxis
GO:0060326 cell chemotaxis
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0000793 condensed chromosome
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR009071 High mobility group box domain
PFAM PF00505
PF09011
PRINTS
PIRSF
SMART SM00398
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P40673
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 618297
UniGene
RefSeq NP_001032705
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC109755
GenPept AAI09756

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca