Version 5.4
Bos taurus Protein: FST
Summary
InnateDB Protein IDBP-680802.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FST
Protein Name Follistatin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000004318
InnateDB Gene IDBG-629398 (FST)
Protein Structure
UniProt Annotation
Function Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0048185 activin binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0002244 hematopoietic progenitor cell differentiation
GO:0007276 gamete generation
GO:0007389 pattern specification process
GO:0008585 female gonad development
GO:0030509 BMP signaling pathway
GO:0031069 hair follicle morphogenesis
GO:0032926 negative regulation of activin receptor signaling pathway
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043616 keratinocyte proliferation
GO:0045596 negative regulation of cell differentiation
GO:0051798 positive regulation of hair follicle development
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002350 Kazal domain
IPR003645 Follistatin-like, N-terminal
IPR015369 Follistatin/Osteonectin EGF domain
IPR017878 TB domain
PFAM PF00050
PF07648
PF09289
PF00683
PRINTS
PIRSF
SMART SM00280
SM00274
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P50291
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 327681
UniGene Bt.405
RefSeq NP_786995
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY775795 BC133637 L21716
GenPept AAA30522 AAI33638 AAX19140

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca