InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FST

Summary

InnateDB Gene

IDBG-629398.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FST

Gene Name

Follistatin

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003329

Encoded Proteins

IDBP-680802

Follistatin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134363:
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:25588642-25594057

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000004318

ENSBTAP00000004318

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0048185	activin binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0002244	hematopoietic progenitor cell differentiation
GO:0007276	gamete generation
GO:0007389	pattern specification process
GO:0008585	female gonad development
GO:0030509	BMP signaling pathway
GO:0031069	hair follicle morphogenesis
GO:0032926	negative regulation of activin receptor signaling pathway
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043616	keratinocyte proliferation
GO:0045596	negative regulation of cell differentiation
GO:0051798	positive regulation of hair follicle development