Version 5.4
Bos taurus Protein: BT.21975
Summary
InnateDB Protein IDBP-681185.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.21975
Protein Name perforin-1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000001336
InnateDB Gene IDBG-629772 (BT.21975)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0022829 wide pore channel activity
Biological Process
GO:0002357 defense response to tumor cell
GO:0002418 immune response to tumor cell
GO:0019835 cytolysis
GO:0051260 protein homooligomerization
GO:0051607 defense response to virus
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0044194 cytolytic granule
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR020864 Membrane attack complex component/perforin (MACPF) domain
PFAM PF00168
PF01823
PRINTS PR00360
PIRSF
SMART SM00239
SM00457
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q863Z7
UniProt Splice Variant
Entrez Gene 369025
UniGene Bt.21975
RefSeq NP_001137207
HUGO HGNC:9360
OMIM
CCDS
HPRD
IMGT
EMBL AY266136 AY313172 DAAA02061851
GenPept AAP23215 AAQ82904

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca