Version 5.4
Bos taurus Protein: PCBD1
Summary
InnateDB Protein IDBP-681234.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCBD1
Protein Name Pterin-4-alpha-carbinolamine dehydratase
Synonyms DCoH; PCD; PHS;
Species Bos taurus
Ensembl Protein ENSBTAP00000015750
InnateDB Gene IDBG-629809 (PCBD1)
Protein Structure
UniProt Annotation
Function Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Cytoplasmic and/or nuclear. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 86 interaction(s) predicted by orthology.
Predicted by orthology
Total 86 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004505 phenylalanine 4-monooxygenase activity
GO:0005515 protein binding
GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity
GO:0016829 lyase activity
GO:0042802 identical protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006729 tetrahydrobiopterin biosynthetic process
GO:0051289 protein homotetramerization
GO:0051291 protein heterooligomerization
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001533 Transcriptional coactivator/pterin dehydratase
PFAM PF01329
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3ZBD3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 530736
UniGene Bt.48735
RefSeq NP_001193403
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103434
GenPept AAI03435

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca