InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPN4

Summary

InnateDB Protein

IDBP-68130.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPN4

Protein Name

protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)

Synonyms

MEG; PTPMEG; PTPMEG1;

Species

Homo sapiens

Ensembl Protein

ENSP00000263708

InnateDB Gene

IDBG-68128 (PTPN4)

Protein Structure

UniProt Annotation

Function

May act at junctions between the membrane and the cytoskeleton.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	15 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0009898	cytoplasmic side of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000299 FERM domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR000798 Ezrin/radixin/moesin like
IPR001478 PDZ domain
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR012151 Protein-tyrosine phosphatase, non-receptor type-3, -4
IPR014847 FERM adjacent (FA)
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR029021 Protein-tyrosine phosphatase-like
IPR029071 Ubiquitin-related domain

PFAM