Version 5.4
Homo sapiens Gene: PTPN4
Summary
InnateDB Gene IDBG-68128.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPN4
Gene Name protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
Synonyms MEG; PTPMEG; PTPMEG1
Species Homo sapiens
Ensembl Gene ENSG00000088179
Encoded Proteins
IDBP-68130
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
IDBP-385188
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
IDBP-385190
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
IDBP-385191
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
IDBP-385192
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
IDBP-385193
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
IDBP-591702
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:119759631-119983818
Strand Forward strand
Band q14.2
Transcripts
ENST00000263708 ENSP00000263708
ENST00000420482 ENSP00000405763
ENST00000433888 ENSP00000411364
ENST00000430976 ENSP00000395603
ENST00000431283 ENSP00000387457
ENST00000441089 ENSP00000394706
ENST00000460162
ENST00000460289
ENST00000488279 ENSP00000438445
ENST00000485247
ENST00000488896
ENST00000469511
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 15 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0009898 cytoplasmic side of plasma membrane
GO:0019898 extrinsic component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026384
View Gene Order
ENSBTAG00000020855
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.469809 Hs.611806
RefSeq NM_002830
HUGO
OMIM
CCDS CCDS2129
HPRD 01471
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca