Homo sapiens Gene: PTPN4
Summary
InnateDB Gene IDBG-68128.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPN4
Gene Name protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
Synonyms MEG; PTPMEG; PTPMEG1;
Species Homo sapiens
Ensembl Gene ENSG00000088179
Encoded Proteins
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:119759631-119983818
Strand Forward strand
Band q14.2
Transcripts
ENST00000263708 ENSP00000263708
ENST00000420482 ENSP00000405763
ENST00000433888 ENSP00000411364
ENST00000430976 ENSP00000395603
ENST00000431283 ENSP00000387457
ENST00000441089 ENSP00000394706
ENST00000460162
ENST00000460289
ENST00000488279 ENSP00000438445
ENST00000485247
ENST00000488896
ENST00000469511
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 15 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0009898 cytoplasmic side of plasma membrane
GO:0019898 extrinsic component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.469809 Hs.611806
RefSeq NM_002830
HUGO
OMIM
CCDS CCDS2129
HPRD 01471
IMGT
EMBL
GenPept
RNA Seq Atlas