InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PANX1

Summary

InnateDB Protein

IDBP-68157.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PANX1

Protein Name

pannexin 1

Synonyms

MRS1; PX1; UNQ2529;

Species

Homo sapiens

Ensembl Protein

ENSP00000227638

InnateDB Gene

IDBG-68155 (PANX1)

Protein Structure

UniProt Annotation

Function

Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. {ECO:0000269PubMed:16908669, ECO:0000269PubMed:20829356}.

Subcellular Localization

Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255PROSITE-ProRule:PRU00351}. Cell junction, gap junction {ECO:0000269PubMed:16908669, ECO:0000269PubMed:17715132}. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255PROSITE- ProRule:PRU00351}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0003779	actin binding
GO:0005102	receptor binding
GO:0005243	gap junction channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0015267	channel activity
GO:0022840	leak channel activity
GO:0044325	ion channel binding
GO:0046982	protein heterodimerization activity
GO:0051015	actin filament binding
GO:0055077	gap junction hemi-channel activity
GO:0097110	scaffold protein binding

Biological Process

GO:0002931	response to ischemia
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0007267	cell-cell signaling
GO:0007268	synaptic transmission
GO:0033198	response to ATP
GO:0034214	protein hexamerization
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0045087	innate immune response
GO:0050715	positive regulation of cytokine secretion
GO:0050717	positive regulation of interleukin-1 alpha secretion
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005921	gap junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032059	bleb
GO:0043234	protein complex