InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PANX1

Summary

InnateDB Gene

IDBG-68155.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PANX1

Gene Name

pannexin 1

Synonyms

MRS1; PX1; UNQ2529

Species

Homo sapiens

Ensembl Gene

ENSG00000110218

Encoded Proteins

IDBP-68157

pannexin 1

IDBP-382206

pannexin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:94128928-94181972

Strand

Forward strand

Band

q21

Transcripts

ENST00000227638	ENSP00000227638
ENST00000436171	ENSP00000411461

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0003779	actin binding
GO:0005102	receptor binding
GO:0005243	gap junction channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0015267	channel activity
GO:0022840	leak channel activity
GO:0044325	ion channel binding
GO:0046982	protein heterodimerization activity
GO:0051015	actin filament binding
GO:0055077	gap junction hemi-channel activity
GO:0097110	scaffold protein binding

Biological Process

GO:0002931	response to ischemia
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0007267	cell-cell signaling
GO:0007268	synaptic transmission
GO:0033198	response to ATP
GO:0034214	protein hexamerization
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0045087	innate immune response
GO:0050715	positive regulation of cytokine secretion
GO:0050717	positive regulation of interleukin-1 alpha secretion
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005921	gap junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032059	bleb
GO:0043234	protein complex