Version 5.4
Bos taurus Protein: CTSH
Summary
InnateDB Protein IDBP-681615.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTSH
Protein Name Pro-cathepsin HCathepsin H mini chainCathepsin HCathepsin H heavy chainCathepsin H light chain
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000014593
InnateDB Gene IDBG-630170 (CTSH)
Protein Structure
UniProt Annotation
Function Important for the overall degradation of proteins in lysosomes. {ECO:0000250}.
Subcellular Localization Lysosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004177 aminopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0016505 peptidase activator activity involved in apoptotic process
GO:0016787 hydrolase activity
GO:0030108 HLA-A specific activating MHC class I receptor activity
GO:0070324 thyroid hormone binding
Biological Process
GO:0001656 metanephros development
GO:0001913 T cell mediated cytotoxicity
GO:0002250 adaptive immune response
GO:0002764 immune response-regulating signaling pathway
GO:0006508 proteolysis
GO:0008284 positive regulation of cell proliferation
GO:0010628 positive regulation of gene expression
GO:0010634 positive regulation of epithelial cell migration
GO:0010813 neuropeptide catabolic process
GO:0010815 bradykinin catabolic process
GO:0010952 positive regulation of peptidase activity
GO:0030335 positive regulation of cell migration
GO:0031638 zymogen activation
GO:0031648 protein destabilization
GO:0032526 response to retinoic acid
GO:0033619 membrane protein proteolysis
GO:0043066 negative regulation of apoptotic process
GO:0043129 surfactant homeostasis
GO:0045766 positive regulation of angiogenesis
GO:0060448 dichotomous subdivision of terminal units involved in lung branching
GO:0070371 ERK1 and ERK2 cascade
GO:0097067 cellular response to thyroid hormone stimulus
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
GO:0097208 alveolar lamellar body
Protein Structure and Domains
PDB ID
InterPro IPR000668 Peptidase C1A, papain C-terminal
IPR013201 Proteinase inhibitor I29, cathepsin propeptide
PFAM PF00112
PF08246
PRINTS PR00705
PIRSF
SMART SM00645
SM00848
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3T0I2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 510524
UniGene Bt.52393
RefSeq NP_001029557
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102386
GenPept AAI02387

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca