InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SYT1

Summary

InnateDB Protein

IDBP-681648.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYT1

Protein Name

Synaptotagmin-1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000008338

InnateDB Gene

IDBG-630189 (SYT1)

Protein Structure

UniProt Annotation

Function

May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0046872	metal ion binding
GO:0048306	calcium-dependent protein binding
GO:0050750	low-density lipoprotein particle receptor binding

Biological Process

GO:0006810	transport
GO:0007269	neurotransmitter secretion
GO:0016079	synaptic vesicle exocytosis

Cellular Component

GO:0005737	cytoplasm
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030136	clathrin-coated vesicle
GO:0030141	secretory granule
GO:0030672	synaptic vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0042584	chromaffin granule membrane
GO:0042734	presynaptic membrane
GO:0043005	neuron projection
GO:0045202	synapse