InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SYT1

Summary

InnateDB Gene

IDBG-630189.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYT1

Gene Name

Synaptotagmin-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000034693

Encoded Proteins

IDBP-681648

Synaptotagmin-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067715:
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:8836101-9062297

Strand

Forward strand

Band

Transcripts

ENSBTAT00000008338

ENSBTAP00000008338

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0046872	metal ion binding
GO:0048306	calcium-dependent protein binding
GO:0050750	low-density lipoprotein particle receptor binding

Biological Process

GO:0006810	transport
GO:0007269	neurotransmitter secretion
GO:0016079	synaptic vesicle exocytosis

Cellular Component

GO:0005737	cytoplasm
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030136	clathrin-coated vesicle
GO:0030141	secretory granule
GO:0030672	synaptic vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0042584	chromaffin granule membrane
GO:0042734	presynaptic membrane
GO:0043005	neuron projection
GO:0045202	synapse