Version 5.4
Bos taurus Protein: PFDN2
Summary
InnateDB Protein IDBP-681649.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFDN2
Protein Name Prefoldin subunit 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000026841
InnateDB Gene IDBG-630209 (PFDN2)
Protein Structure
UniProt Annotation
Function Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0051086 chaperone mediated protein folding independent of cofactor
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016272 prefoldin complex
Protein Structure and Domains
PDB ID
InterPro IPR002777 Prefoldin beta-like
IPR009053 Prefoldin
PFAM PF01920
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A1A4P5
PhosphoSite PhosphoSite-
TrEMBL Q862M6
UniProt Splice Variant
Entrez Gene 404138
UniGene Bt.1544
RefSeq NP_001073690
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB098954 BC126786
GenPept AAI26787 BAC56444

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca