Version 5.4
Bos taurus Protein: BCL2A1
Summary
InnateDB Protein IDBP-681656.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCL2A1
Protein Name Bcl-2-related protein A1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000000977
InnateDB Gene IDBG-630216 (BCL2A1)
Protein Structure
UniProt Annotation
Function Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006915 apoptotic process
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
Protein Structure and Domains
PDB ID
InterPro IPR002475 Bcl2-like
IPR013282 Bcl-2-related protein A1
IPR026298 Blc2 family
PFAM PF00452
PRINTS PR01867
PR01862
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3C2I0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282151
UniGene Bt.11884
RefSeq NP_001032177
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB195549 BC123574
GenPept AAI23575 BAE46584

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca